My setup is similar, but has a few differences. This is just for those that are into experimenting:
LE: Kindle
DT: Ngata, Gregg (99 PRC), Cody [Note: In definite running situations, I'll often sub Cody in, however you have to be careful with him getting super tired if he's in all game.]
RE: Pryce
LOLB: Johnson (Subs: Gooden, Mcclain)
MLB: Lewis (Subs: Ellerbe, Mcclain, Gooden)
ROLB: Suggs (Subs: Gooden, Mcclain)
CB: Foxworth, Wilson, Webb, Washington, Carr
FS: Reed
SS: It depends. In definite passing situations, I leave in Landry (77 CTH). In definite running situations, I bring in Tom Z. If blitzing the SS out of the 4-6 (Normal or Bear), Tom Z. is way more effective as well.
As I run the 4-6 book, I always ensure Suggs is subbed in at RE in Dime and Qtrs packages. If a team has a truly dominant OT, sometimes I'll put Kindle on that player's side (i.e. Ryan Clady, Jake Long, etc.) and I'll move Suggs away from that spot so as to abuse the opposite OT.
This may be a personal observation, but I seem to see players with high Finesse Move ratings beating elite Tackles more than those with high Power Move ratings. I'm sure there is more to it than simply those ratings (i.e. because players with high FMV typically have higher agility and speed, etc.), however it's still worth noting. For example, consider manually rushing Suggs against the weaker OT and having Kindle (opposite side) in a QB Contain. Kindle's speed in Contains can often negate an elite OT.