i am by no means a madden stallion so take my set up with a grain of salt. i am sure someone in these forums probably has a better set up that far exceeds mine, but alas.. here it is - my 46 d, speed set up
RE - clay matthews (86 speed)
LE - brad jones (82 speed)
DT1 - cj wilson (he is there since he is the fastest DL out of the DTs)
DT2 - bj raji
LOLB - doesn't matter since he won't see the field in the speed package
MLB - hawk (82 speed)
ROLB - doesn't matter since he won't see the field in the speed package
CB1 - charles woodson
CB2 - tramon williams
CB3 - sam shields (he takes over LB spot in the speed package)
CB4 - nick collins (92 speed - he takes over LB spot in the speed package)
FS - house (87 speed - i think)
SS - morgan burnett
i may be off in some of my speed ratings as i don't have the game on or ratings website pulled up as i typed this out. to get matthews at a LE or RE spot, take him out as starter at OLB, go over to LE or RE and scroll down and you should be able to select him to a DE spot.
as i said before, take this lineup with a grain of salt, but this set up helps me wins games.... sometimes