It says substitutions. That has to mean by pressing R1 because it even speaks about how you can use the substitution packages which are on the play call screen..
According to those guidelines, you aren't allowed to have a SS at OLB. I wish you could, but apparently you can't.
At MLG, you can only do QB Sneaks if it's 1 yd to go.. so 1st and 1, 2nd and 1.. and so on.
Designed QB Sneaks were permitted to be run anytime before I believe.. so anything called "QB Sneak" or "QB Draw" had no limitations.
I thought from undercenter, you just had to take the first step away from the LOS, not two steps.. but maybe that was just shotgun.