Take auto-sprint & auto-strafe off.
If you have auto-sprint on, you will have a weird delay when sprinting away from a blitz.
I was labbing with a friend, and he had auto-sprint on. We were trying play-action plays to get our QB on the outside to rush with.. Vince Young always got this weird delayed animation when running away. [You are supposed to hold R2 to make your QB go into scramble mode just like last year] Apparently it is broken. I had the same team & playbook as him.. I used the same play, and VY for me wasn't delayed, I sprinted perfectly..
Auto-Sprint: Outrun your blockers frequently. Scrambling as a QB is at a disadvantage with this on.
Auto-Strafe: I want to choose when I strafe.. You just run the risk of the CPU strafing when you don't want to, causing you to run slower.. You can't run as fast when you strafe.. It could make you strafe in a bad situation. The football field is too dynamic for the CPU to know exactly when you want to sprint or strafe.