A few things might/probably have been mentioned already, but here is what I would like to see:
Ability to audible certain linemen to do certain things. Being able to assign a certain lineman to a certain defensive player etc.
The option to have a Db defend a certain route, and then the ability to cancel his assignment mid play. For example your opponent has thrown a curl route to receiver x on 3rd and 6 3 times. So you audible your cb to defend curl route.. And after the snap if you see him running a different route, a cancel option.
Even the same as I said above, but pertaining to a whole offensive play. Again, an option to cancel within the same time frame as the availability to commit?
Allowing press coverage on single receivers and and shading them left/right.
I have also seen the video where they sub O-linemen for qbs and they still can block. Make ratings like strength, and attributes such as height and weight matter more/at all.
I might like if a back like AP would sometimes alternate between his elusiveness and trucking.
Don't like DT's being able to contain.
Like being able to blue route RBS.
Like to see custom playbooks, heard that might be/is coming.